Critical contribution of liver natural killer T cells to a murine model of hepatitis
Adoptive Cell Transfer
CD1
Autoimmune Hepatitis
DOI:
10.1073/pnas.040566697
Publication Date:
2002-07-26T14:31:44Z
AUTHORS (6)
ABSTRACT
Natural killer T (NKT) cells constitute a distinct subpopulation of with unique antigen specificity, prompt effector functions, and an unusual tissue distribution. NKT are especially abundant in the liver, but their physiological function this organ remains unclear. In present study, we examined possible contribution to murine model hepatitis induced by i.v. injection Con A. CD1-deficient mice lacking were highly resistant A-induced hepatitis. Adoptive transfer hepatic isolated from wild-type mice, not FasL-deficient gld sensitized Furthermore, adoptive mononuclear Upon A administration, rapidly up-regulated cell surface FasL expression FasL-mediated cytotoxicity. At same time, underwent apoptosis leading rapid disappearance liver. These results implicated on liver pathogenesis hepatitis, suggesting similar pathogenic role human diseases such as autoimmune
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