The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells

• DOI: 10.1073/pnas.0405928102
• Publication Date: 2005-01-22T01:41:41Z
• Authors: Emmelie Å. Jansson; Alexandra Are; Gediminas Greicius; I-Chun Kuo; Denise Kelly; Velmurugesan Arul...; Sven Pettersson
• Keywords: Adenomatous polyposis coli; Beta-catenin; Cell fate determination

Control of colon cell fate in adenocarcinomas is disrupted, part, due to aberrant Wnt/β-catenin signaling. The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has been implicated the development cancers. In adenomatous polyposis coli multiple intestinal neoplasia (APC Min ) mouse cancer model, PPARγ expression colonic mucosa markedly altered. addition, protein levels are elevated, possibly through sequestration by activated β-catenin lines. Induction pathway LiCl also elevated and induced PPARγ-dependent reporter endogenous target genes. Mechanistically, PPARγ, interactions with T transcription factor (Tcf)-4, may be a determinant likely Wnt cells.