Dysregulation of the fibroblast growth factor system in major depression

• DOI: 10.1073/pnas.0406788101
• Publication Date: 2004-10-14T00:13:38Z
• Authors: S. J. Evans; P. V. Choudary; C. R. Neal; J. Z. Li; M. P. Vawter; H. Tomita; J. F. Lopez; R. C. Thompson; F. Meng; J. D. Stead; D. M. Walsh; R. M. Myers; W. E. Bunney; S. J. Watson; E. G. Jones; H. Akil
• Keywords: FGF1; Depression

In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions brains from human subjects with major depressive disorder (MDD). This altered gene expression was discovered by microarray analysis tissue MDD, bipolar, and nonpsychiatric control verified quantitative real-time PCR and, importantly, a separate cohort MDD subjects. Furthermore, show, through specific serotonin reuptake inhibitor (SSRI)-treated non-SSRI-treated the observed changes FGF are not secondary to drug treatment. Rather, attenuated SSRIs may thus be partially responsible for mechanism action these drugs. We also make available gene-expression profile all other factors receptors detected postmortem samples.