Innate control of adaptive immunity via remodeling of lymph node feed arteriole

• DOI: 10.1073/pnas.0506190102
• Publication Date: 2005-11-01T01:34:23Z
• Authors: Kelly A. Soderberg; Geoffrey W. Payne; Ayuko Sato; Ruslan Medzhitov; Steven S. Segal; Akiko Iwasaki
• Keywords: Arteriole

The adaptive immune system relies on rare cognate lymphocytes to detect pathogen-derived antigens. Naïve recirculate through secondary lymphoid organs in search of antigen. Here, we show that the naïve-lymphocyte recirculation pattern is controlled at level innate recognition, independent antigen-specific stimulation. We demonstrate inflammation-induced lymphocyte recruitment lymph node mediated by remodeling primary feed arteriole, and its physiological role increase efficiency screening for lymphocytes. Our data reveal a mechanism control immunity: increasing pool naïve detection foreign antigens via regulation vascular input local node.