Hypoxia-inducible myoglobin expression in nonmuscle tissues

• DOI: 10.1073/pnas.0508270103
• Publication Date: 2006-02-10T01:34:15Z
• Authors: Jane Fraser; Luciane Vieira de...; Deborah Ward; Huw H. Rees; Daryl R. Williams; Yongchang Fang; Andrew Brass; Andrew Y. Gracey; Andrew R. Cossins
• Keywords: Neuroglobin; Hypoxia; Cardiac muscle

Myoglobin (Myg) is an oxygen-binding hemoprotein that widely thought to be expressed exclusively in oxidative skeletal and cardiac myocytes, where it plays a key role coping with chronic hypoxia. We now show hypoxia-tolerant fish model, Myg also range of other tissues, including liver, gill, brain. Moreover, expression transcript was substantially enhanced during hypoxia, the fold-change induction being far greater liver than muscle. By using 2D gel electrophoresis, we have confirmed expresses protein corresponding Myg-1 significantly up-regulated discovered second, unique isoform, distinct from neuroglobin, which neural tissue but whose unaffected by environmental Both observations nonmuscle brain-specific isoform are unprecedented, indicating may play much wider previously understood might function protection tissues deep hypoxia ischemia as well reoxygenation reperfusion injury.