A microRNA expression signature of human solid tumors defines cancer gene targets

• DOI: 10.1073/pnas.0510565103
• Publication Date: 2006-02-04T01:48:52Z
• Authors: Stefano Volinia; George A. Calin; Chang-Gong Liu; Stefan Ambs; Amelia Cimmino; Fabio Petrocca; Rosa Visone; Marilena Iorio; Claudia Roldo; Manuela Ferracin; Robyn L. Prueitt; Nozumu Yanaihara; Giovanni Lanza; Aldo Scarpa; Andrea Vecchione; Massimo Negrini; Curtis C. Harris; Carlo M. Croce
• Keywords: Retinoblastoma

Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression are differentially expressed in normal tissues cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, pancreatic tumors, we identified solid miRNA signature composed by large portion of overexpressed miRNAs. Among these miRNAs some with well characterized association, such as miR-17-5p , miR-20a miR-21 miR-92 miR-106a miR-155 . The predicted targets for the significantly enriched protein-coding tumor suppressors oncogenes ( P < 0.0001). A number targets, RB1 (Retinoblastoma 1) TGFBR2 (transforming growth factor, beta receptor II) genes were confirmed experimentally. Our results indicate that extensively involved pathogenesis tumors support their function either dominant or recessive genes.