A biosynthetic pathway for anandamide
Anandamide
2-Arachidonoylglycerol
Phospholipase D
DOI:
10.1073/pnas.0601832103
Publication Date:
2006-08-28T22:10:40Z
AUTHORS (11)
ABSTRACT
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide also generated macrophages where its endotoxin (LPS)-induced synthesis has been implicated hypotension of septic shock advanced liver cirrhosis. can be from membrane precursor, N -arachidonoyl phosphatidylethanolamine (NAPE) through cleavage phospholipase D (NAPE–PLD). Here we document biosynthetic pathway for anandamide mouse brain RAW264.7 that involves C (PLC)-catalyzed NAPE to generate lipid, phosphoanandamide, which subsequently dephosphorylated phosphatases, including PTPN22, previously described as protein tyrosine phosphatase. Bacterial mediated exclusively PLC/phosphatase pathway, up-regulated LPS, whereas NAPE–PLD down-regulated LPS functions salvage when compromised. Both PTPN22 endocannabinoids have autoimmune diseases, suggesting may pharmacotherapeutic target.
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