A therapeutic target for prostate cancer based on angiogenin-stimulated angiogenesis and cancer cell proliferation

• DOI: 10.1073/pnas.0606708103
• Publication Date: 2006-09-14T01:21:43Z
• Authors: Norie Yoshioka; Li Wang; Koji Kishimoto; Takanori Tsuji; Guo-fu Hu
• Keywords: Angiogenin

Human angiogenin is progressively up-regulated in the prostate epithelial cells during development of cancer from intraepithelial neoplasia (PIN) to invasive adenocarcinoma. Mouse most gene AKT-induced PIN prostate-restricted AKT transgenic mice. These results prompted us study role that plays cancer. Here, we report that, addition its well established mediating angiogenesis, also directly stimulates cell proliferation. Angiogenin undergoes nuclear translocation PC-3 human grown both vitro and Thus, knocking down expression adenocarcinoma inhibits ribosomal RNA transcription, proliferation, colony formation soft agar, xenograft growth athymic Blockade by aminoglycoside antibiotic neomycin inhibited tumor mice was accompanied a decrease proliferation angiogenesis. suggest has dual effect, angiogenesis may serve as molecular target for drug development. Blocking could have combined benefit antiangiogenesis chemotherapy treating