Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation

• DOI: 10.1073/pnas.0607245103
• Publication Date: 2006-12-14T02:56:21Z
• Authors: Xi Li; Yinghua Peng; Jinsong Ren; Xiaogang Qu
• Keywords: Nanodevice; Nuclease; Cleave

As the leading nanodevice candidate, single-walled carbon nanotubes (SWNTs) have potential therapeutic applications in gene therapy and novel drug delivery. We found that SWNTs can inhibit DNA duplex association selectively induce human telomeric i-motif formation by binding to 5′-end major groove under physiological conditions or even at pH 8.0. SWNT was studied UV melting, NMR, S1 nuclease cleavage, CD, competitive FRET methods. These results suggest might intriguing modulate structures vivo , like biologically relevant B-A B-Z transitions, which is of great interest for design cancer therapy.