Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

• DOI: 10.1073/pnas.0610024104
• Publication Date: 2007-01-25T05:50:27Z
• Authors: Maria Mirotsou; Zhongyan Zhang; Arjun Deb; Lunan Zhang; Massimiliano Gnecchi; Nicolas Noiseux; Hui Mu; Alok Pachori; Victor Dzau
• Keywords: 0301 basic medicine; 570; Cell Survival; 610; MESENCHYMAL STEM CELL; Mesoderm; Rats, Sprague-Dawley; Mice; 03 medical and health sciences; PARACRINE ACTION; Animals; Myocytes, Cardiac; beta Catenin; Gene Expression Profiling; Myocardium; Stem Cells; Membrane Proteins; Rats; Up-Regulation; 3. Good health; Mice, Inbred C57BL; MYOCARDIAL REPAIR; Female; Proto-Oncogene Proteins c-akt; Signal Transduction

Stem cell therapy has emerged as a promising tool for the treatment of variety diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using comprehensive functional genomic strategy, show secreted frizzled related protein 2 (Sfrp2) is key factor mediates myocardial survival and after ischemic injury. Sfrp2 known to modulate Wnt signaling, demonstrate cardiomyocytes treated with increase cellular beta-catenin up-regulate expression antiapoptotic genes. These findings reveal role played by in mediating effects Akt-mesenchymal on identify modulation signaling therapeutic target heart disease.