A role for IκB kinase 2 in bipolar spindle assembly

• DOI: 10.1073/pnas.0706493104
• Publication Date: 2007-10-16T00:48:04Z
• Authors: Jeffrey T. Irelan; Thomas J. Murphy; Paul D. DeJesus; Hsiangling Teo; DingYue Xu; Maria A. Gomez-Fe...; Yingyao Zhou; Loren J. Miraglia; Daniel R. Rines; Inder M. Verma; David J. Sharp; Vinay Tergaonkar; Sumit K. Chanda
• Keywords: IκB kinase; Aurora B kinase

IkappaB kinase 2 (IKK2 or IKKbeta) is a component of the IKK complex that coordinates cellular response to diverse set extracellular stimuli, including cytokines, microbial infection, and stress. In an external stimulus, activated, resulting in phosphorylation subsequent proteasome-mediated degradation proteins. This event triggers nuclear import NF-kappaB transcription factor, which activates genes regulate variety fundamental biological processes, immune response, cell survival, development. Here, we define essential role for IKK2 normal mitotic progression maintenance spindle bipolarity. Chemical genetic perturbation promotes formation multipolar spindles chromosome missegregation. Depletion results deregulation Aurora A protein stability coincident hyperactivation putative substrate, motor KIF11. These data support function as antagonist signaling during mitosis. Additionally, our indicate direct genome underscore potential oncogenic consequences targeting this therapeutic intervention.