Functional integration across a gradient of corticostriatal channels controls UP state transitions in the dorsal striatum

• DOI: 10.1073/pnas.0711113105
• Publication Date: 2008-06-04T02:48:50Z
• Authors: Fernando Kasanetz; Luis A. Riquelme; Valeria Della-Mag...; Patricio O'Donnell; M. Gustavo Murer
• Keywords: Neocortex; Local field potential

Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome such remains be identified. Here, we examined whether plateau depolarizations (UP states) relate better active epochs local field potentials recorded from closely related areas than those less-related areas. Our results show that, anesthetized rats, the coordination between regions obeys mediolateral gradient keeps track slow wave trajectory neocortex. Moreover, activity one area induced phase advances UP state onset delays termination nonmatching regions, reflecting existence connections encode large-scale as subthreshold influences on projection neurons.