Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity

• DOI: 10.1073/pnas.0802345105
• Publication Date: 2008-06-10T01:09:57Z
• Authors: T. K. Smith; H. A. Hager; R. Francis; D. M. Kilkenny; C. W. Lo; D. M. Bader
• Keywords: CDC42; Small GTPase

Bves is an integral membrane protein with no determined function and homology to proteins outside of the Popdc family. It widely expressed throughout development in myriad organisms. Here, we demonstrate interaction between guanine nucleotide exchange factor T (GEFT), a GEF for Rho-family GTPases. This represents first identification any that has direct physical member GEFT are shown colocalize adult skeletal muscle. We also exogenous expression reduces Rac1 Cdc42 activity levels while not affecting active RhoA. Consistent repression activity, show changes speed cell locomotion roundness result from Bves. Modulation GTPase signaling by would be highly consistent previously described phenotypes occurring upon disruption wide variety model systems. Therefore, propose as novel regulator cascades.