CXCR4–CCR5: A couple modulating T cell functions

• DOI: 10.1073/pnas.0804286105
• Publication Date: 2008-07-16T03:53:32Z
• Authors: Rita Lucia Contento; Barbara Molon; Cedric Boularan; Tullio Pozzan; Santos Manes; Stefano Marullo; Antonella Viola
• Keywords: CCL13; CCR1; CCR10; CXC chemokine receptors; CC chemokine receptors; Immunological synapse; Chemokine receptor CCR5

Chemokines and their receptors direct leukocyte migration among blood, lymph tissues. Evidence has recently accumulated that, besides chemotactic functions, chemokine are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presenting cells, the CCR5 CXCR4 recruited into immunological synapse, where they deliver costimulatory signals. However, molecular mechanisms allowing signaling versatility of unknown. Here, we describe functional interaction between to exert specific biological functions modulate lymphocyte We demonstrate simultaneous expression cooperation required for chemokine-induced costimulation at synapse. In addition, provide evidence a physical association two in complex activates distinct functions. suggest represents one key strategy plasticity chemokines.