CXCR4–CCR5: A couple modulating T cell functions

CCL13 CCR1 CCR10 CXC chemokine receptors CC chemokine receptors Immunological synapse Chemokine receptor CCR5
DOI: 10.1073/pnas.0804286105 Publication Date: 2008-07-16T03:53:32Z
ABSTRACT
Chemokines and their receptors direct leukocyte migration among blood, lymph tissues. Evidence has recently accumulated that, besides chemotactic functions, chemokine are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presenting cells, the CCR5 CXCR4 recruited into immunological synapse, where they deliver costimulatory signals. However, molecular mechanisms allowing signaling versatility of unknown. Here, we describe functional interaction between to exert specific biological functions modulate lymphocyte We demonstrate simultaneous expression cooperation required for chemokine-induced costimulation at synapse. In addition, provide evidence a physical association two in complex activates distinct functions. suggest represents one key strategy plasticity chemokines.
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