Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry

• DOI: 10.1073/pnas.0806485105
• Publication Date: 2008-10-14T00:54:14Z
• Authors: Nitin Gogtay; Allen Lu; Alex D. Leow; Andrea D. Klunder; Agatha D. Lee; Alex Chavez; Deanna Greenstein; Jay N. Giedd; Arthur W. Toga; Judith L. Rapoport; Paul M. Thompson
• Keywords: Right hemisphere

Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based morphometry to visualize white (WM) growth abnormalities COS throughout Using high-dimensional elastic image registration, compared 3D maps local WM rates patients healthy children over a 5-year period, based on analyzing longitudinal brain MRIs from 12 controls matched for age, gender, scan interval. showed up 2.2% slower per year than ( P = 0.02, all values corrected). The greatest differences were right hemisphere 0.006). This asymmetry was attributable left rate mapped 0.037) but not controls. reached 2.6% 0.0002). only 1.3% trend 0.066). In COS, associated with improvement Children's Global Assessment Scale R 0.64, 0.029). Growth reduced this process appeared progress front-to-back (frontal-parietal) fashion, effect lower IQ. correlated functional prognosis visualized as detailed maps. Finally, these findings also confirm that GM deficits seen are result overgrowth.