Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction

• DOI: 10.1073/pnas.0900491106
• Publication Date: 2009-05-29T01:24:43Z
• Authors: Rita Z. Goldstein; Nelly Alia-Klein; Dardo Tomasi; Jean Honorio Carr...; Thomas Maloney; Patricia A. Woicik; Ruiliang Wang; Frank Telang; Nora D. Volkow
• Keywords: Salience (neuroscience); Disengagement theory; Cingulate cortex

Anterior cingulate cortex (ACC) hypoactivations during cognitive processing characterize drug addicted individuals as compared with healthy controls. However, impaired behavioral performance or task disengagement may be crucial factors. We hypothesized that ACC would documented in groups matched for on an emotionally salient task. Seventeen current cocaine use disorders (CUD) and 17 demographically controls underwent functional magnetic resonance imaging of a rewarded cue-reactivity previously shown to engage the ACC. Despite lack group differences objective subjective task-related performance, CUD showed more throughout this Nevertheless, intensity emotional salience contributed results: (i) largest rostroventral [Brodmann Area (BA) 10, 11, implicated default brain function] most condition (drug words highest available monetary reward), had least task-induced craving; (ii) caudal-dorsal (BA 32) especially (neutral no reward) frequent use; (iii) responses both these major subdivisions were positively intercorrelated only. In conclusion, users cannot attributed difficulty disengagement. modulates proportion severity. Interventions strengthen reactivity interconnectivity beneficial enhancing top-down monitoring emotion regulation strategy reduce impulsive compulsive behavior addiction.