The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

• DOI: 10.1073/pnas.0906749106
• Publication Date: 2009-10-28T01:56:01Z
• Authors: Justin R. DiAngelo; Michelle L. Bland; Shelly Bambina; Sara Cherry; Morris J. Birnbaum
• Keywords: 0301 basic medicine; Fat Body; Toll-Like Receptors; Immunity; Forkhead Transcription Factors; Bacterial Infections; 3. Good health; Phosphatidylinositol 3-Kinases; Protein Transport; 03 medical and health sciences; Drosophila melanogaster; Food; Animals; Drosophila Proteins; Insulin; Female; Signal Transduction; Subcellular Fractions

Innate immunity is the primary and most ancient defense against infection. Although critical to survival, coordinating protection a foreign organism energetically costly, creating need reallocate substrates from nonessential functions, such as growth nutrient storage. However, mechanism by which infection or inflammation leads reduction in energy utilization these dispensable processes not well understood. Here, we demonstrate that activation of Toll signaling pathway selectively fat body, major immune lipid storage organ fruit fly, Drosophila melanogaster, both induction reallocation resources. body suppresses insulin within cells non-autonomously throughout organism, leading decrease stores growth. These data suggest communication between two regulatory systems evolved means divert times organismal acute requirement combating