Random cell movement promotes synchronization of the segmentation clock

• DOI: 10.1073/pnas.0907122107
• Publication Date: 2010-03-02T04:55:41Z
• Authors: Koichiro Uriu; Yoshihiro Morishita; Yoh Iwasa
• Keywords: Somitogenesis; Paraxial mesoderm; Oscillation (cell signaling); Cell synchronization

In vertebrate somitogenesis, the expression of segmentation clock genes oscillates and oscillation is synchronized over nearby cells. Both experimental theoretical studies have shown that synchronization among cells realized by intercellular interaction via Delta-Notch signaling. However, following questions emerge: (i) During dynamic rearrangement relative cell positions observed in posterior presomitic mesoderm. Can a state be stably sustained under random movement? (ii) Experimental reported can recovered about 10 or fewer cycles after complete loss synchrony. such quick recovery not possible according to previous models. this paper, we first show numerical modeling movement. We also find for initial perturbation, much faster it wider range reaction parameters than case without When mesoderm rectangular, achieved if exchange their locations more with neighbors located along longer side domain. Finally, discuss enhancement movement occurs several different models genes.