Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

• DOI: 10.1073/pnas.0907359106
• Publication Date: 2009-09-26T01:52:43Z
• Authors: Jun Yu; Carlos Fernández-...; Yajaira Suarez; Michael Schleicher; Zhengrong Hao; Paulette L. Wright; Annarita DiLorenzo; Themis R. Kyriakides; William C. Sessa
• Keywords: Arteriogenesis; Homing (biology); Infiltration (HVAC)

Blood vessel formation during ischemia and wound healing requires coordination of the inflammatory response with genes that regulate blood assembly. Here we show reticulon family member 4B, aka Nogo-B, is upregulated in to necessary for flow recovery secondary healing. Mice lacking Nogo-B exhibit reduced arteriogenesis angiogenesis are linked a decrease macrophage infiltration gene expression vivo. Bone marrow-derived macrophages isolated from Nogo knock-out mice have spreading chemotaxis due impaired Rac activation. marrow reconstitution experiments myeloid cells promote homing functional after limb ischemia. Thus, endogenous coordinates macrophage-mediated inflammation arteriogenesis, healing, control.