Biophysical model for gamma rhythms in the olfactory bulb via subthreshold oscillations

• DOI: 10.1073/pnas.0910964106
• Publication Date: 2009-12-09T03:58:14Z
• Authors: Jorge N. Brea; Leslie M. Kay; Nancy J. Kopell
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Biophysics; Action Potentials; Cytoplasmic Granules; Olfactory Bulb

Gamma oscillations in the olfactory bulb can be produced as an interaction of subthreshold oscillations (STOs) in the mitral cells (MCs) with inhibitory granule cells (GCs). The mechanism does not require that the GCs spike, and we work in a regime in which the MCs fire at rates lower than the fast gamma rhythm they create. The frequency of the network is that of the STOs, allowing the gamma to be modulated in amplitude with only small changes in frequency. Gamma oscillations could also be obtained with spiking GCs, but only for GCs firing close to population rate. Our mechanism differs from the more standard description of the gamma oscillation, in which the the decay time of the inhibitory cells is critical to the frequency of the network.