Acute in vivo exposure to interferon-γ enables resident brain dendritic cells to become effective antigen presenting cells

• DOI: 10.1073/pnas.0911509106
• Publication Date: 2009-11-12T03:19:33Z
• Authors: Andres Gottfried-...; Ulrike W. Kaunzner; Juliana Idoyaga; Jennifer C. Felger; Bruce S. McEwen; Karen Bulloch
• Keywords: CD11c

Dendritic cells (DC) are the professional antigen presenting (APC) that bridge innate and adaptive immune system. Previously, in a CD11c/EYFP transgenic mouse developed to study DC functions, we anatomically mapped phenotypically characterized discrete population of EYFP + within microglia termed brain dendritic (bDC). In this study, advanced our knowledge function these its chimeras, using acute stimuli stereotaxically inoculated IFNγ or IL-4 into CNS. The administration increased number bDC but did not recruit peripheral IFNγ, IL-4, upregulated expression levels major histocompatibility class II (MHC-II). addition, IFNγ-activated induced antigen-specific naïve CD4 T proliferate secrete Th1/Th17 cytokines. Activated were also able stimulate CD8 cells. Collectively, data reveal Th1 cytokine Th2 IL4, induces up-regulate MHC-II become competent APC.