In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

• DOI: 10.1073/pnas.0913683107
• Publication Date: 2010-03-23T02:36:27Z
• Authors: Nichole R. Blatner; Andreas Bonertz; Philipp Beckhove; Eric C. Cheon; Seth B. Krantz; Matthew Strouch; Juergen Weitz; Moritz Koch; Amy L. Halverson; David J. Bentrem; Khashayarsha Khazaie
• Keywords: Proinflammatory cytokine; Regulatory T cell

T-regulatory cells (Treg) and mast (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions autoimmunity. Here, we demonstrate that both human CRC murine polyposis outcome this interaction generation potently suppressive but proinflammatory (ΔTreg). These shut down IL10, gain potential express IL17, switch from suppressing promoting MC expansion degranulation. This change also brought about by direct coculture Treg, culture medium containing IL6 IL2. deficiency bone marrow mice susceptible eliminated IL17 production polyp infiltrating did not significantly affect growth polyps Treg. IL6-deficient could generate Thus, induce function escalate inflammation without losing T-cell–suppressive properties. needed process.