Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies

• DOI: 10.1073/pnas.1008306107
• Publication Date: 2010-09-21T04:37:18Z
• Authors: Ryan T. Canolty; Karunesh Ganguly; Steven W. Kennerley; Charles F. Cadieu; Kilian Koepsell; Jonathan D. Wallis; Jose M. Carmena
• Keywords: Local field potential; Nerve net; Premovement neuronal activity

Hebb proposed that neuronal cell assemblies are critical for effective perception, cognition, and action. However, evidence brain mechanisms coordinate multiple coactive remains lacking. Neuronal oscillations have been suggested as one possible mechanism assembly coordination. Prior studies shown spike timing depends upon local field potential (LFP) phase proximal to the body, but few examined dependence of spiking on distal LFP phases in other areas far from neuron or influence LFP-LFP coupling between spiking. We investigated these interactions by recording LFPs single-unit activity using microelectrode arrays several then used a unique probabilistic multivariate distribution model full pattern phases, electrodes. Here we show single neurons ensembles dynamic patterns oscillatory areas, addition effects phase. Neurons prefer similar exhibit changes rates, whereas with different preferences divergent responses, providing basic bind together into coordinated assemblies. Surprisingly, phase-coupling-based rate correlations independent interneuron distance. Phase-coupling correlate behavior neural function remain stable over days. These findings suggest enable selective control distributed functional