Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species

Pleckstrin homology domain AKT2 Proto-Oncogene Proteins c-akt
DOI: 10.1073/pnas.1011665108 Publication Date: 2011-06-14T18:03:48Z
ABSTRACT
Isoform-specific signaling of Akt, a major hub and prominent therapeutic target, remained poorly defined until recently. Subcellular distribution, tissue-specific expression, substrate specificity, posttranslational modifications are believed to underlie isoform-specific Akt. The studies reported here show inhibition Akt2 activity under physiologically relevant conditions oxidation created by PDGF-induced reactive oxygen species. Combined MS functional assays identified Cys124 located in the linker region between N-terminal pleckstrin homology domain catalytic kinase as one unique regulatory redox sites with consequence on PDGF-stimulated glucose uptake. A model is proposed describing increased endogenous induced extracellular cues such PDGF activity.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (29)
CITATIONS (128)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....