Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting

• DOI: 10.1073/pnas.1013827107
• Publication Date: 2010-11-04T02:49:55Z
• Authors: Nicole Joller; Stefan S. Weber; Andreas J. Müller; Roman Spörri; Petra Selchow; Peter Sander; Hubert Hilbi; Annette Oxenius
• Keywords: Intracellular parasite

The protective effect of antibodies (Abs) is generally attributed to neutralization or complement activation. Using Legionella pneumophila and Mycobacterium bovis bacillus Calmette–Guérin as a model, we discovered an additional mechanism Ab-mediated protection effective against intracellular pathogens that normally evade lysosomal fusion. We show Fc receptor (FcR) engagement by Abs, which can be temporally spatially separated from bacterial infection, renders the host cell nonpermissive for replication targets lysosomes. This process strictly dependent on kinases involved in FcR signaling but not protein synthesis protease Based these findings, propose whereby Abs subverts strategies degradation.