Regulation of synaptic stability by AMPA receptor reverse signaling

• DOI: 10.1073/pnas.1015163108
• Publication Date: 2010-12-21T04:23:52Z
• Authors: Beth Ripley; Stefanie Otto; Katie Tiglio; Megan E. Williams; Anirvan Ghosh
• Keywords: Neuroligin; Silent synapse; Long-term depression; Neurexin

The establishment of neuronal circuits relies on the stabilization functionally appropriate connections and elimination inappropriate ones. Here we report that postsynaptic AMPA receptors play a critical role in regulating stability glutamatergic synapses. Removal surface leads to decrease number excitatory presynaptic inputs, whereas overexpression increases synapse stability. Furthermore, along with Neuroligin-1 293T cells is sufficient stabilize inputs from cortical neurons onto heterologous cells. by not dependent receptor-mediated current instead structural interactions mediated N-terminal domain glutamate receptor 2 (GluR2) subunit. These observations indicate transsynaptic signaling extracellular GluR2 regulates terminals.