RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation

• DOI: 10.1073/pnas.1019059108
• Publication Date: 2011-01-12T03:18:05Z
• Authors: Lin-Jia Jiang; Nan-Nan Zhang; Fei Ding; Xian-Yang Li; Lei Chen; Hong-Xin Zhang; Wu Zhang; Sai-Juan Chen; Zhu-Gang Wang; Jun-Min Li; Zhu Chen; Jiang Zhu
• Keywords: STAT1; Mediator; IRF1

RA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-β promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or RA signaling process in acute myeloid leukemia (AML) cells, however, where obvious induction observed. Here, we show that functionally contributes IFN-α plus RA-triggered growth inhibition of AML cells. Interestingly, although itself under regulation STAT1, a major intracellular signal mediator, circumstances which it does not stimulate IPS-1, conversely augments STAT1 activation induce IFN-stimulatory expression and inhibit cell proliferation. Thus, our results unveil previously undescribed activity regulating cellular proliferation cells via independent its classic role sensing invasion trigger type transcription.