Schwann cell spectrins modulate peripheral nerve myelination

• DOI: 10.1073/pnas.1019600108
• Publication Date: 2011-04-26T03:05:55Z
• Authors: Keiichiro Susuki; Alya R. Raphael; Yasuhiro Ogawa; Michael C. Stanke...; Elior Peles; William S. Talbot; Matthew N. Rasband
• Keywords: Schwann cell; Neuroglia

During peripheral nerve development, Schwann cells ensheathe axons and form myelin to enable rapid efficient action potential propagation. Although myelination requires profound changes in cell shape, how neuron–glia interactions converge on the cytoskeleton induce these is unknown. Here, we demonstrate that submembranous cytoskeletal proteins αII βII spectrin are polarized colocalize with signaling molecules known modulate vitro. Silencing expression of spectrins inhibited vitro, remyelination vivo. Furthermore, was disrupted motor nerves zebrafish lacking spectrin. Finally, loss significantly reduces both F-actin Nectin-like protein, Necl4, at contact site between axons. Therefore, propose integrate mediated by membrane into actin-dependent rearrangements necessary for myelination.