The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

• DOI: 10.1073/pnas.1031527100
• Publication Date: 2003-05-13T18:28:41Z
• Authors: Davor Pavlović; David C. A. Neville; Olivier Argaud; Baruch Blumberg; Raymond A. Dwek; Wolfgang B. Fischer; Nicole Zitzmann
• Keywords: Iminosugar

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the surrogate bovine viral diarrhea virus. presents a potential target for therapy.