Mismatch repair-dependent mutagenesis in nondividing cells

• DOI: 10.1073/pnas.1115361109
• Publication Date: 2012-04-03T05:11:02Z
• Authors: Gina P. Rodriguez; Nina V. Romanova; Gaobin Bao; N. Cynthia Rouf; Yoke Wah Kow; Gray F. Crouse
• Keywords: DNA Replication; 0301 basic medicine; Saccharomyces cerevisiae Proteins; Base Sequence; Genotype; Models, Genetic; Saccharomyces cerevisiae; DNA Mismatch Repair; 3. Good health; DNA-Binding Proteins; 03 medical and health sciences; Mutagenesis; Mutation; Tryptophan Synthase; DNA, Fungal; DNA Damage

Mismatch repair (MMR) is a major DNA pathway in cells from all branches of life that removes replication errors strand-specific manner, such mismatched nucleotides are preferentially removed the newly replicated strand DNA. Here we demonstrate role for MMR helping create new phenotypes nondividing cells. We show mispairs yeast escape during can later be subject to activity strand-independent manner cells, resulting either fully wild-type or mutant sequence. In one case, this responsible what appears adaptive mutation. This could contribute formation tumors arising and also mutagenesis observed somatic hypermutation Ig genes.