Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

• DOI: 10.1073/pnas.1120246109
• Publication Date: 2012-06-05T14:05:21Z
• Authors: Cong Jin; Mifang Liang; Junyu Ning; Wen Gu; Hong Jiang; Wei Wu; Fushun Zhang; Chuan Li; Quanfu Zhang; Hua Zhu; Ting Chen; Ying Han; Weilun Zhang; Shuo Zhang; Qin Wang; Lina Sun; Qinzhi Liu; Jiandong Li; Tao Wang; Qiang Wei; Shiwen Wang; Ying Deng; Chuan Qin; Dexin Li
• Keywords: Leukocytopenia; Pathogenesis

The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis SFTSV. We are unique in establishing infectious model C57/BL6 mice, resulting hallmark symptoms and leukocytopenia. Viral RNA histopathological changes were identified spleen, liver, kidney. However, replication was only found which suggested spleen be principle target organ Moreover, number macrophages platelets largely increased SFTSV colocalized cytoplasm red pulp spleen. In vitro cellular assays further revealed that adhered mouse facilitated phagocytosis primary macrophages, combination vivo findings, suggests SFTSV-induced is clearance circulating virus-bound splenic macrophages. Thus, this study elucidated pathogenic mechanisms a resembling human disease.