On a fundamental structure of gene networks in living cells

• DOI: 10.1073/pnas.1200790109
• Publication Date: 2012-03-06T04:33:43Z
• Authors: Nataly Kravchenko...; Alexander Levitzki; Andrew Goldstein; Varda Rotter; A. Gross; F. Remacle; R. D. Levine
• Keywords: Gene regulatory network; Expression (computer science); Component (thermodynamics); Cell type

Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression variety of species, organs, cell types, we found that biological systems similarly comprised relatively unchanging hardware-like pattern. Orthogonal software-like transcripts vary greatly, even among tumors the same type from different individuals. Two distinguishable classes could be identified within component: those highly expressed stable an adaptable subset with lower respond external stimuli. Importantly, demonstrate this structure is conserved across organisms. Deletions core predicted result mortality. The provides conceptual thermodynamic-like framework for analysis gene-expression levels networks their variations diseased cells.