Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8 + T-cell differentiation

• DOI: 10.1073/pnas.1207327109
• Publication Date: 2012-06-05T14:05:21Z
• Authors: Tuoqi Wu; Andreas Wieland; Koichi Araki; Carl W. Davis; Lilin Ye; J. Scott Hale; Rafi Ahmed
• Keywords: Memory cell

MicroRNAs are important regulators of various developmental and physiological processes. However, their roles in the CD8 + T-cell response not well understood. Using an acute viral infection model, we show that microRNAs miR-17-92 cluster strongly induced after activation, down-regulated clonal expansion, further silenced during memory development. promotes cell-cycle progression effector T cells, its expression is critical to rapid expansion these cells. excessive enhances mammalian target rapamycin (mTOR) signaling skews differentiation toward short-lived terminal Failure down-regulate leads a gradual loss cells defective central cell Therefore, our results reveal temporal pattern by antigen-specific infection, precise control which