Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4

• DOI: 10.1073/pnas.1217091110
• Publication Date: 2013-08-20T01:59:24Z
• Authors: Xiaoban Xin; Murilo Rodrigues; Mahaa Umapathi; Fabiana Kashiwabuchi; Tao Ma; Savalan Babapoor-...; Shuang Wang; Jiadi Hu; Imran Bhutto; Derek S. Welsbie; Elia J. Duh; James T. Handa; Charles G. Eberhart; Gerard Lutty; Gregg L. Semenza; Silvia Montaner; Akrit Sodhi
• Keywords: Angiopoietin 2; Angiopoietin; Vascular permeability

Significance Ischemic retinopathies include a diverse group of diseases in which immature retinal vasculature or damage to mature vessels leads ischemia. The anticipated rise the worldwide prevalence diabetes will result concurrent increase number patients with vision impairment from diabetic eye disease, most common cause ischemic retinopathy. We set out identify novel hypoxia-inducible genes that promote vascular permeability and may therefore play role pathogenesis disease. demonstrate angiopoietin-like 4 (ANGPTL4) is up-regulated by transcriptional enhancer, factor-1 hypoxic Müller cells, can permeability. Our findings suggest ANGPTL4 be potential therapeutic target for retinopathies.