Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis

• DOI: 10.1073/pnas.1218872110
• Publication Date: 2013-05-14T04:55:35Z
• Authors: Sang-Wook Park; Wei Li; Andrea Viehhauser; Bin He; Soonok Kim; Anders K. Nilsson; Mats X. Andersson; Joshua D. Kittle; Madana M. R. Amba...; Sheng Luan; Alan R. Esker; Dorothea Tholl; Daniela Cimini; Mats Ellerström; Gitta Coaker; Thomas K. Mitchell; Andy Pereira; Karl-Josef Dietz; Christopher B. La...
• Keywords: Cyclophilin

The jasmonate family of phytohormones plays central roles in plant development and stress acclimation. However, the architecture their signaling circuits remains largely unknown. Here we describe a binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-responsive cellular redox homeostasis. (+)-12-oxo-phytodienoic acid (OPDA) promotes CYP20-3 to form complex with serine acetyltransferase 1, triggers formation hetero-oligomeric cysteine synthase O -acetylserine(thiol)lyase B chloroplasts. then activates sulfur assimilation that leads increased levels thiol metabolites buildup reduction potential. enhanced capacity turn coordinates expression subset OPDA-responsive genes. Thus, conclude is key effector protein links OPDA amino biosynthesis homeostasis responses.