Human placental trophoblasts confer viral resistance to recipient cells

• DOI: 10.1073/pnas.1304718110
• Publication Date: 2013-07-02T04:42:22Z
• Authors: Elizabeth Delorme...; Rogier B. Donker; Jean-Francois Mou...; Tianjiao Chu; Avraham Bayer; Yingshi Ouyang; Tianyi Wang; Donna B. Stolz; Saumendra N. Sarkar; Adrian E. Morelli; Yoel Sadovsky; Carolyn B. Coyne
• Keywords: Trophoblast; Exosome

Placental trophoblasts form the interface between fetal and maternal environments serve to limit maternal–fetal spread of viruses. Here we show that cultured primary human placental are highly resistant infection by a number viruses and, importantly, confer this resistance nonplacental recipient cells exosome-mediated delivery specific microRNAs (miRNAs). We miRNA members chromosome 19 cluster, which almost exclusively expressed in placenta, packaged within trophoblast-derived exosomes attenuate viral replication induction autophagy. Together, our findings identify an unprecedented paracrine and/or systemic function uses transfer unique set placental-specific effector miRNAs directly communicate with or target regulate their immunity infections.