Topological friction strongly affects viral DNA ejection
Time Factors
Friction
02 engineering and technology
Molecular Dynamics Simulation
Virus Internalization
Monte Carlo simulations
Biomechanical Phenomena
DNA knotting; Monte Carlo simulations
DNA, Viral
Pressure
Nucleic Acid Conformation
Bacteriophages
DNA knotting
0210 nano-technology
DOI:
10.1073/pnas.1306601110
Publication Date:
2013-11-23T02:38:40Z
AUTHORS (4)
ABSTRACT
Significance Bacteriophages are viruses which infect bacteria. Many of these contain double-stranded DNA packed to almost crystalline density and exploit the resulting pressure trigger ejection into infected bacterial cell. We show that kinetics is highly sensitive ordering knotting packaged which, in turn, controlled by self-interactions. The latter favor ordered spools have a lower effective or topological friction than disordered entangled structures. also find torus knots (which can be drawn on surface doughnut) exit bacteriophage easily; while complex twist formed linking ends twisted loop) slow down may stall ejection.
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