Topological friction strongly affects viral DNA ejection

Time Factors Friction 02 engineering and technology Molecular Dynamics Simulation Virus Internalization Monte Carlo simulations Biomechanical Phenomena DNA knotting; Monte Carlo simulations DNA, Viral Pressure Nucleic Acid Conformation Bacteriophages DNA knotting 0210 nano-technology
DOI: 10.1073/pnas.1306601110 Publication Date: 2013-11-23T02:38:40Z
ABSTRACT
Significance Bacteriophages are viruses which infect bacteria. Many of these contain double-stranded DNA packed to almost crystalline density and exploit the resulting pressure trigger ejection into infected bacterial cell. We show that kinetics is highly sensitive ordering knotting packaged which, in turn, controlled by self-interactions. The latter favor ordered spools have a lower effective or topological friction than disordered entangled structures. also find torus knots (which can be drawn on surface doughnut) exit bacteriophage easily; while complex twist formed linking ends twisted loop) slow down may stall ejection.
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