Surge of neurophysiological coherence and connectivity in the dying brain

• DOI: 10.1073/pnas.1308285110
• Publication Date: 2013-08-13T01:53:00Z
• Authors: Jimo Borjigin; UnCheol Lee; Tiecheng Liu; Dinesh Pal; Sean Huff; Daniel Klarr; Jennifer Sloboda; Jason Hernandez; Michael M. Wang; George A. Mashour
• Keywords: Neurophysiology

The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of immediately following arrest has not been systematically investigated. In this study, we performed continuous electroencephalography in rats undergoing experimental and analyzed changes power density, coherence, directed connectivity, cross-frequency coupling. We identified a transient surge synchronous gamma oscillations that occurred within first 30 s after preceded isoelectric electroencephalogram. Gamma were global highly coherent; moreover, frequency band exhibited striking increase anterior–posterior-directed connectivity tight phase-coupling both theta alpha waves. High-frequency activity near-death exceeded levels found conscious waking state. These data demonstrate mammalian can, albeit paradoxically, generate neural correlates heightened processing at near-death.