Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis

• DOI: 10.1073/pnas.1310655110
• Publication Date: 2013-09-24T05:25:39Z
• Authors: Nicole D. Powell; Erica K. Sloan; Michael T. Bailey; Jesusa M. G. Arevalo; Gregory E. Miller; Edith Chen; Michael S. Kobor; Brenda F. Reader; John F. Sheridan; Steven W. Cole
• Keywords: Proinflammatory cytokine; Myelopoiesis; Chronic Stress

Significance Chronic exposure to adverse social environments is associated with increased risk of disease, and stress-related increases in the expression proinflammatory genes appear contribute these effects. The present study identifies a biological mechanism such effects ability sympathetic nervous system up-regulate bone marrow production immature, monocytes. These are mediated by β-adrenergic receptors myelopoietic growth factor GM-CSF, suggest new targets for interventions protect health context chronic stress.