A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions

• DOI: 10.1073/pnas.1312420110
• Publication Date: 2013-11-12T04:48:45Z
• Authors: Mark Windheim; Jennifer H. South...; Elisabeth Kremmer; Lucy Chaplin; Doris Urlaub; Christine S. Falk; Maren Claus; Janine Mihm; Myles Braithwaite; Kevin Dennehy; Harald Renz; Martina Sester; Carsten Watzl; Hans-Gerhard Burgert
• Keywords: Ectodomain

Significance Human adenoviruses encode Early region 3 (E3) proteins that manipulate the host immune response to establish an infection or persist longer. To date, only a few E3 functions from single adenovirus species (C) have been characterized, all of which act directly on infected cells. Here we describe secreted protein is uniquely expressed by D adenoviruses. This targets noninfected leukocytes using cell surface phosphatase as receptor. We provide evidence this interaction suppresses leukocyte activation and effector functions, implying can affect distant site infection.