Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

• DOI: 10.1073/pnas.1312937110
• Publication Date: 2013-10-15T00:21:48Z
• Authors: Shigenobu Kishino; Michiki Takeuchi; Si-Bum Park; Akiko Hirata; Nahoko Kitamura; Jun Kunisawa; Hiroshi Kiyono; Ryo Iwamoto; Yosuke Isobe; Makoto Arita; Hiroyuki Arai; Kazumitsu Ueda; Jun Shima; Satomi Takahashi; Kenzo Yokozeki; Sakayu Shimizu; Jun Ogawa
• Keywords: Molecular Sequence Data; 610; Sequence Homology; hydratase; conjugated linoleic acid; Mice; 03 medical and health sciences; Tandem Mass Spectrometry; Animals; Amino Acid Sequence; Cloning, Molecular; DNA Primers; 0303 health sciences; Base Sequence; Sequence Analysis, DNA; lipid nutrition; 540; Lipid Metabolism; Specific Pathogen-Free Organisms; Gastrointestinal Tract; Multigene Family; Fatty Acids, Unsaturated; biohydrogenation; fatty acid isomerase; Oxidoreductases; Oxidation-Reduction; Metabolic Networks and Pathways; Chromatography, Liquid; Lactobacillus plantarum

Significance Microorganisms in the gastrointestinal tract interact with their host many ways. Lipid metabolism by microbes generates multiple fatty acid species that can affect health. In representative gut bacterium Lactobacillus plantarum , we revealed a metabolism, saturation of polyunsaturated acid, hydroxy acids, oxo conjugated and partially saturated trans -fatty acids as intermediates. Furthermore, analysis mice suggests modifies composition host. Therefore, functional investigations lipid metabolisms may provide new methods for improving our health altering related to onset metabolic syndrome.