Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila

• DOI: 10.1073/pnas.1313058111
• Publication Date: 2014-04-29T07:37:37Z
• Authors: Christen Kerry Mirth; Hui Yuan Tang; Sasha C. Makohon-...; Samy Salhadar; Rewatee H. Gokhale; Raechel D. Warner; Takashi Koyama; Lynn M. Riddiford; Alexander W. Shin...
• Keywords: Ecdysone; 0303 health sciences; developmental hormones; Forkhead Transcription Factors; Denervation; size control; Juvenile Hormones; 03 medical and health sciences; Drosophila melanogaster; Corpora Allata; Larva; Basic Helix-Loop-Helix Transcription Factors; Animals; Body Size; Drosophila Proteins; Insulin; insect physiology; Signal Transduction

Significance Understanding how organisms regulate their body size is a fundamental problem in biology. Body regulation involves the careful integration of mechanisms that control growth rate with those duration. In insects, developmental hormones such as juvenile hormone and ecdysone transitions The conserved insulin-signaling pathway regulates rates. Our studies reveal an intimate link between three, whereby controls by regulating synthesis, which turn modifies insulin signaling. vertebrates, androgens estrogens interact signaling to influence tumor growth. By studying context interactions, our data features have important consequences for understanding cancer