Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

• DOI: 10.1073/pnas.1314197110
• Publication Date: 2013-11-27T04:29:43Z
• Authors: Erik R. Anderson; Matthew Taylor; Xiang Xue; Sadeesh K. Ramakr...; Angelical Martin; Liwei Xie; Bryce X. Bredell; Sara Gardenghi; Stefano Rivella; Yatrik M. Shah
• Keywords: DMT1; Hypoxia

Significance Several distinct congenital disorders can lead to tissue-iron overload with anemia. Tissue-iron accumulation is the major cause of mortality in these patients. Intestinal hypoxia-inducible factor-2α (HIF2α) and its downstream target gene divalent metal transporter-1 (DMT1) are essential for iron absorption during times increased demand. However, role intestinal HIF2α/DMT1 signaling axis has not been assessed. We demonstrate that HIF2α DMT1 small intestine highly activated early mouse models anemic disruption their expression prevent improve disorders. These results ideal therapeutic targets iron-overload