Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1

• DOI: 10.1073/pnas.1314268111
• Publication Date: 2014-01-22T04:02:30Z
• Authors: Ee Lyn Ooi; Stephanie T. Chan; Noell E. Cho; Courtney Wilkins; Jessica Woodward; Meng Li; Ushio Kikkawa; Timothy Tellinghu...; Michael Gale; Takeshi Saito
• Keywords: STAT1; Host factors

Significance IFN-stimulated genes (ISGs) are the antiviral effectors and a key component of intracellular innate immunity. Inefficient induction ISGs is linked to poor disease outcome allows viruses establish persistent infection. Hepatitis C virus (HCV) chronically infects over 200 million people worldwide leading cause advanced liver diseases, such as cirrhosis cancer. In this work, our high-throughput cDNA screening identified novel host factor, tyrosine kinase nonreceptor 1, that suppresses HCV life cycle through STAT1 activation ISGs. Our findings add an important unique player in JAK-STAT signaling advance understanding IFN biology. This will contribute improvement strategy against human pathogenic infectious disease.