Superpriming of synaptic vesicles after their recruitment to the readily releasable pool
0301 basic medicine
0303 health sciences
Phosphodiesterase Inhibitors
Models, Neurological
Excitatory Postsynaptic Potentials
Nerve Tissue Proteins
Actins
Pyrrolidinones
Rats
Diglycerides
Rats, Sprague-Dawley
Kinetics
03 medical and health sciences
Calmodulin
Type C Phospholipases
Animals
Calcium Signaling
Synaptic Vesicles
Estrenes
Brain Stem
DOI:
10.1073/pnas.1314427110
Publication Date:
2013-08-27T02:24:39Z
AUTHORS (4)
ABSTRACT
Significance
During sustained nerve activity, synapses must continuously recycle vesicles. We used the unique opportunities for quantitative analysis offered by the calyx of Held synapse to study late stages in the process that renders vesicles release-ready. We dissect two sequential steps with distinct pharmacology and kinetics, the characterization of which is essential for an understanding of molecular mechanisms of transmitter release and short-term plasticity.
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CITATIONS (90)
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