Superpriming of synaptic vesicles after their recruitment to the readily releasable pool

0301 basic medicine 0303 health sciences Phosphodiesterase Inhibitors Models, Neurological Excitatory Postsynaptic Potentials Nerve Tissue Proteins Actins Pyrrolidinones Rats Diglycerides Rats, Sprague-Dawley Kinetics 03 medical and health sciences Calmodulin Type C Phospholipases Animals Calcium Signaling Synaptic Vesicles Estrenes Brain Stem
DOI: 10.1073/pnas.1314427110 Publication Date: 2013-08-27T02:24:39Z
ABSTRACT
Significance During sustained nerve activity, synapses must continuously recycle vesicles. We used the unique opportunities for quantitative analysis offered by the calyx of Held synapse to study late stages in the process that renders vesicles release-ready. We dissect two sequential steps with distinct pharmacology and kinetics, the characterization of which is essential for an understanding of molecular mechanisms of transmitter release and short-term plasticity.
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