Superpriming of synaptic vesicles after their recruitment to the readily releasable pool

• DOI: 10.1073/pnas.1314427110
• Publication Date: 2013-08-27T02:24:39Z
• Authors: Jae Sung Lee; Won-Kyung Ho; Erwin Neher; Suk-Ho Lee
• Keywords: Secretory Vesicle

Significance During sustained nerve activity, synapses must continuously recycle vesicles. We used the unique opportunities for quantitative analysis offered by calyx of Held synapse to study late stages in process that renders vesicles release-ready. dissect two sequential steps with distinct pharmacology and kinetics, characterization which is essential an understanding molecular mechanisms transmitter release short-term plasticity.