Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy

• DOI: 10.1073/pnas.1315155110
• Publication Date: 2013-11-28T05:07:13Z
• Authors: Roberto Papait; Paola Cattaneo; Paolo Kunderfranco; Carolina Greco; Pierluigi Carullo; Alessandro Guffanti; Valentina Viganò; Giuliano Giuseppe...; Michael V. G. Lat...; Gerd Hasenfuss; Ju Chen; Gianluigi Condorelli
• Keywords: Epigenesis

Cardiac hypertrophy, initially an adaptive response of the myocardium to stress, can progress heart failure. The epigenetic signature underlying this phenomenon is poorly understood. Here, we report on genome-wide distribution seven histone modifications in adult mouse cardiomyocytes subjected a prohypertrophy stimulus vivo. We found set promoters with pattern that distinguishes specific functional classes genes regulated hypertrophy and identified 9,207 candidate active enhancers whose activity was modulated. also analyzed transcriptional network within which these genetic elements act orchestrate gene expression, finding role for myocyte enhancer factor (MEF)2C MEF2A regulating enhancers. propose landscape key determinant expression reprogramming cardiac provide basis understanding chromatin phenomenon.