A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence
Drug Development
DOI:
10.1073/pnas.1315860110
Publication Date:
2013-11-05T01:58:48Z
AUTHORS (14)
ABSTRACT
Significance Chronic bacterial infections, such as those caused by Mycobacterium tuberculosis ( Mtb ), continue to claim the lives of millions people. New antibiotics are needed treat these but their development is hindered a lack targets whose inhibition quickly eradicates pathogens and prevents survival drug-tolerant persisters. We describe unique dual-control (DUC) switch that combines repression transcription controlled proteolysis silence gene activities in . By conditionally inactivating ’s nicotinamide adenine dinucleotide synthetase, we demonstrate DUC can identify proteins this pathogen requires for growth nonreplicating persistence vitro during infections. Targeting holds promise yielding drugs shorten duration antibacterial chemotherapies.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (43)
CITATIONS (134)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....