Chromatin fiber polymorphism triggered by variations of DNA linker lengths

0301 basic medicine Polymorphism, Genetic Static Electricity Molecular Conformation DNA Chromatin Nucleosomes Rats Histones 03 medical and health sciences Gene Expression Regulation Models, Chemical Animals Nucleic Acid Conformation Protein Structure, Quaternary Algorithms
DOI: 10.1073/pnas.1315872111 Publication Date: 2014-05-21T01:53:54Z
ABSTRACT
Significance The structure of the chromatin fiber remains one of the most fundamental open biological questions because structure dictates many template-directed processes. We use coarse-grained modeling to investigate systematically how variations in the linker DNA length that arise naturally for chromatin in different tissues, species, and cell cycle stages affect fiber architecture. We unravel a natural source of fiber polymorphism, in which irregular interdigitated 10-nm and compact 30-nm fibers coexist. These results suggest how structural diversity can be advantageous for gene regulation activity. Interesting DNA design applications also arise.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (56)
CITATIONS (143)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....