Chromatin fiber polymorphism triggered by variations of DNA linker lengths
0301 basic medicine
Polymorphism, Genetic
Static Electricity
Molecular Conformation
DNA
Chromatin
Nucleosomes
Rats
Histones
03 medical and health sciences
Gene Expression Regulation
Models, Chemical
Animals
Nucleic Acid Conformation
Protein Structure, Quaternary
Algorithms
DOI:
10.1073/pnas.1315872111
Publication Date:
2014-05-21T01:53:54Z
AUTHORS (2)
ABSTRACT
Significance
The structure of the chromatin fiber remains one of the most fundamental open biological questions because structure dictates many template-directed processes. We use coarse-grained modeling to investigate systematically how variations in the linker DNA length that arise naturally for chromatin in different tissues, species, and cell cycle stages affect fiber architecture. We unravel a natural source of fiber polymorphism, in which irregular interdigitated 10-nm and compact 30-nm fibers coexist. These results suggest how structural diversity can be advantageous for gene regulation activity. Interesting DNA design applications also arise.
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