Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

• DOI: 10.1073/pnas.1318376111
• Publication Date: 2014-02-12T05:09:08Z
• Authors: Jeffrey S. Damrauer; Katherine A. Hoadley; David D. Chism; Cheng Fan; Christopher J. Ti...; Sara E. Wobker; Jen Jen Yeh; Matthew I. Milowsky; Gopa Iyer; Joel S. Parker; William Y. Kim
• Keywords: Gene Expression Regulation, Neoplastic; Urinary Bladder Neoplasms; Predictive Value of Tests; Gene Expression Profiling; Cluster Analysis; Humans; Breast Neoplasms; Microarray Analysis; Models, Biological; 3. Good health

Significance The identification of molecular subtype heterogeneity in breast cancer has allowed a deeper understanding of breast cancer biology. We present evidence that there are two intrinsic subtypes of high-grade bladder cancer, basal-like and luminal, which reflect the hallmarks of breast biology. Moreover, we have developed an accurate gene set predictor of molecular subtype, the BASE47, that should allow the incorporation of subtype stratification into clinical trials. Further clinical, etiologic, and therapeutic response associations will be of interest in future investigations.