Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau
Transcriptional Activation
0303 health sciences
Arvicolinae
Apoptosis
15. Life on land
Tibet
Adaptation, Physiological
Cold Temperature
Evolution, Molecular
03 medical and health sciences
Stress, Physiological
Animals
Humans
Tumor Suppressor Protein p53
Hypoxia
DOI:
10.1073/pnas.1320369110
Publication Date:
2013-12-03T04:57:30Z
AUTHORS (13)
ABSTRACT
Significance
This work explores the environmental correlates of variations in codon 104 of the
p53
gene in three mammalian species: two subterranean mammals, highland- and lowland-dwelling wild zokors (
Myospalax baileyi
and
Myospalax cansus
, respectively), and one highland-dwelling aboveground species, the root vole (
Microtus oeconomus
). In
Microtus oeconomus
the codon 104E variation in
p53
suppresses apoptotic gene reactivation and cell apoptosis. In contrast, in
M
.
baileyi
the codon104N variation is responsible for the transactivation of apoptotic genes under three environmental stresses—hypoxia, hypercapnia (acidic stress, high CO
2
), and cold temperature—that characterize its ecological niche in the Tibet plateau. We conclude that p53 in nature is adapted in structure and function in accordance with specific ecological stresses.
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