Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau
Transcriptional Activation
0301 basic medicine
0303 health sciences
Arvicolinae
Apoptosis
15. Life on land
Tibet
Adaptation, Physiological
Cold Temperature
Evolution, Molecular
03 medical and health sciences
Stress, Physiological
Animals
Humans
Tumor Suppressor Protein p53
Hypoxia
DOI:
10.1073/pnas.1320369110
Publication Date:
2013-12-03T04:57:30Z
AUTHORS (13)
ABSTRACT
Significance This work explores the environmental correlates of variations in codon 104 p53 gene three mammalian species: two subterranean mammals, highland- and lowland-dwelling wild zokors ( Myospalax baileyi cansus , respectively), one highland-dwelling aboveground species, root vole Microtus oeconomus ). In 104E variation suppresses apoptotic reactivation cell apoptosis. contrast, M . codon104N is responsible for transactivation genes under stresses—hypoxia, hypercapnia (acidic stress, high CO 2 ), cold temperature—that characterize its ecological niche Tibet plateau. We conclude that nature adapted structure function accordance with specific stresses.
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