Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau

Transcriptional Activation 0301 basic medicine 0303 health sciences Arvicolinae Apoptosis 15. Life on land Tibet Adaptation, Physiological Cold Temperature Evolution, Molecular 03 medical and health sciences Stress, Physiological Animals Humans Tumor Suppressor Protein p53 Hypoxia
DOI: 10.1073/pnas.1320369110 Publication Date: 2013-12-03T04:57:30Z
ABSTRACT
Significance This work explores the environmental correlates of variations in codon 104 p53 gene three mammalian species: two subterranean mammals, highland- and lowland-dwelling wild zokors ( Myospalax baileyi cansus , respectively), one highland-dwelling aboveground species, root vole Microtus oeconomus ). In 104E variation suppresses apoptotic reactivation cell apoptosis. contrast, M . codon104N is responsible for transactivation genes under stresses—hypoxia, hypercapnia (acidic stress, high CO 2 ), cold temperature—that characterize its ecological niche Tibet plateau. We conclude that nature adapted structure function accordance with specific stresses.
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